Nuclear receptor signaling — Flashcards

Flashcard 1: Androgen insensitivity syndrome is caused by a deficiency of _____ in target tissues of males

Answer: androgen receptors

Flashcard 2: Steroid receptors are specific transcription factors that bind to _____ to cause a steroid response

Answer: steroid response elements

Flashcard 3: What class of protein receptor is common to all steroid hormones, thyroid hormones, and vitamins A/D? _____

Answer: Zinc finger

Flashcard 4: How do the receptors bound by steroid and thyroid hormones differ from the receptors bound by peptide hormones?_____

Answer: Peptide hormones bind extracellular receptors

Flashcard 5: Once a steroid hormone has bound its receptor in the cytoplasm or nucleus, the hormone-receptor complex then _____

Answer: dimerizes

Flashcard 6: Placental _____ deficiency is the inability to synthesize estrogens from androgens

Answer: aromatase

Flashcard 7: Within an enhancer, there are domains known as _____, to which specific transcription factors bind

Answer: response elements (RE)

Flashcard 8: NADPH oxidase

Answer: respiratory burst

Extra: O2O2-

Flashcard 9: Give the pathway by which glucagon/Epi regulate glycogen.

Answer: glucagon/Epi, adenylyl cyclase, cAMP, protein kinase A, glycogen phosphorylsae kinase, glycogen phosphorylase

Flashcard 10: Give the pathway by which insulin regulates glycogen.

Answer: insulin, tyrosine kinase receptor, protein phosphatases, inactivated glycogen phosphorylase kinase and glycogen phorphorylase