NF-κB signaling — Flashcards

Flashcard 1: _____ is an arachidonic acid pathway metabolite that causes neutrophil chemotaxis

Answer: LTB4

Flashcard 2: Endotoxin triggers the release of which two cytokines?_____

Answer: TNF and IL-1

Flashcard 3: What type of oncogene is c-MYC, N-MYC, L-MYC?_____

Answer: Transcription factor (nuclear regulator)

Flashcard 4: NADPH oxidase

Answer: respiratory burst

Extra: O2O2-

Flashcard 5: Give the pathway by which glucagon/Epi regulate glycogen.

Answer: glucagon/Epi, adenylyl cyclase, cAMP, protein kinase A, glycogen phosphorylsae kinase, glycogen phosphorylase

Flashcard 6: Give the pathway by which insulin regulates glycogen.

Answer: insulin, tyrosine kinase receptor, protein phosphatases, inactivated glycogen phosphorylase kinase and glycogen phorphorylase

Flashcard 7: If an enyzme is a kinase, what do you know about its function?

Answer: uses ATP to add phosphate group to substrate

Flashcard 8: How does a direct enzyme-linked immunosorbent assay (ELISA) work?

Answer: 1. Patient's blood sample washed over a fixed antibody linked to a color-generating enzyme. 2. Any antibody-antibody-enzyme complex produces color change.

Flashcard 9: What is the function of cyclin proteins?

Answer: regulate cell cycle; concentrations are cyclic and phase-dependent, complex with and activate CDKs

Flashcard 10: When during the cell cycle are CDKs produced?

Answer: always; CDKs are constitutively expressed but inactive without the correct cyclin hence "cyclin-dependent"