MAP kinase pathways — Flashcards

Flashcard 1: Growth factor receptors are _____ (receptor class)

Answer: receptor tyrosine kinases

Flashcard 2: What is the mechanism that results in malignancy from the RAS oncogene?_____

Answer: point mutation

Flashcard 3: What type of oncogene is RAS?_____

Answer: GTP-binding protein (signal transducer)

Flashcard 4: What type of receptor do growth hormones use for their signaling pathways? _____

Answer: Receptor associated tyrosine kinases

Flashcard 5: The NF1 tumor suppressor gene normally codes for neurofibromin, a negative regulator of _____

Answer: RAS

Flashcard 6: What type of oncogene is ALK?_____

Answer: receptor tyrosine kinase

Flashcard 7: Activated Ras (Ras-_____ complex) sends signals to the nucleus

Answer: GTP

Flashcard 8: NADPH oxidase

Answer: respiratory burst

Extra: O2O2-

Flashcard 9: Give the pathway by which glucagon/Epi regulate glycogen.

Answer: glucagon/Epi, adenylyl cyclase, cAMP, protein kinase A, glycogen phosphorylsae kinase, glycogen phosphorylase

Flashcard 10: Give the pathway by which insulin regulates glycogen.

Answer: insulin, tyrosine kinase receptor, protein phosphatases, inactivated glycogen phosphorylase kinase and glycogen phorphorylase