Hedgehog signaling pathway — Flashcards

Flashcard 1: Holoprosencephaly may be related to mutations in the _____ signaling pathway

Answer: sonic hedgehog

Flashcard 2: Targets of JAK (tyrosine kinase associated-receptor pathway) include _____, which cause transcription of new mRNAs and new protein synthesis

Answer: STATs

Flashcard 3: Mutations in which tumor suppressor genes can lead to Tuberous Sclerosis?_____

Answer: TSC1 & TSC2

Flashcard 4: Do noncompetitive inhibitors resemble the substrate?_____

Answer: No

Flashcard 5: _____ growth factor stimulates cell growth via tyrosine kinases

Answer: Epidermal

Flashcard 6: What type of oncogene is ABL?_____

Answer: Tyrosine kinase (signal transducer)

Flashcard 7: NADPH oxidase

Answer: respiratory burst

Extra: O2O2-

Flashcard 8: Give the pathway by which glucagon/Epi regulate glycogen.

Answer: glucagon/Epi, adenylyl cyclase, cAMP, protein kinase A, glycogen phosphorylsae kinase, glycogen phosphorylase

Flashcard 9: Give the pathway by which insulin regulates glycogen.

Answer: insulin, tyrosine kinase receptor, protein phosphatases, inactivated glycogen phosphorylase kinase and glycogen phorphorylase

Flashcard 10: If an enyzme is a kinase, what do you know about its function?

Answer: uses ATP to add phosphate group to substrate