G-protein coupled receptors — Flashcards

Flashcard 1: The intrinsic GTPase activity of Ras can be stimulated by _____

Answer: GTPase Activating Proteins (GAPs)

Flashcard 2: One type of receptor tyrosine kinase is a _____, which dimerizes and auto-phosphorylates upon binding of a hormone or ligand

Answer: monomer

Flashcard 3: Newly synthesized cGMP (from guanylyl cyclase activity) activates _____, which phosphorylates specific proteins responsible for physiologic actions

Answer: protein kinase G

Flashcard 4: G proteins have _____ subunits (number of subunits)

Answer: three

Flashcard 5: What type of receptor do growth hormones use for their signaling pathways? _____

Answer: Receptor associated tyrosine kinases

Flashcard 6: _____ facilitate dissociation of GDP so that GTP can bind more rapidly, increasing the rate of G protein activation

Answer: Guanine nucleotide releasing factors (GRFs)

Flashcard 7: NADPH oxidase

Answer: respiratory burst

Extra: O2O2-

Flashcard 8: Give the pathway by which glucagon/Epi regulate glycogen.

Answer: glucagon/Epi, adenylyl cyclase, cAMP, protein kinase A, glycogen phosphorylsae kinase, glycogen phosphorylase

Flashcard 9: Give the pathway by which insulin regulates glycogen.

Answer: insulin, tyrosine kinase receptor, protein phosphatases, inactivated glycogen phosphorylase kinase and glycogen phorphorylase

Flashcard 10: If an enyzme is a kinase, what do you know about its function?

Answer: uses ATP to add phosphate group to substrate