Molecular Genetics — Flashcards

Flashcard 801: What type of oncogene is PDGFB?_____

Answer: Growth factor

Flashcard 802: Which type of antibody digestion results in a bivalent F(ab')2 fragment and degraded Fc fragments? _____

Answer: Pepsin cleavage

Flashcard 803: A _____ is type of DNA mutation in which a purine is mutated to another purine (or pyrimidine to pyrimidine)

Answer: transition

Flashcard 804: Is adrenoleukodystrophy an X-linked or autosomal defect?_____

Answer: X-linked

Flashcard 805: What is the mode of inheritance of type III familial dyslipidemia?_____

Answer: Autosomal Recessive

Flashcard 806: What chromosome is Ig heavy chain located on? _____

Answer: Chromosome 14

Flashcard 807: What type of oncogene is JAK2?_____

Answer: tyrosine kinase

Flashcard 808: What process is used embryologically to cause "Lyonization"_____

Answer: DNA Methylation

Flashcard 809: β-thalassemia is usually caused by gene _____.

Answer: Mutations (specifically point mutations in splice sites and promoter sequences)

Extra: In contrast, **α-thalassemia** is usually caused by gene **deletions**.

Flashcard 810: The _____ subunits of the anterior pituitary hormones TSH, FSH, and LH are different and are responsible for the unique biologic activity of each hormone.

Answer: beta

Extra: The alpha subunits of TSH, LH, FSH, and hCG are identical. The beta subunit provides the biological specificity.