Molecular Genetics — Flashcards

Flashcard 741: Topoisomerase _____ induces breaks in single strands of DNA

Answer: I

Flashcard 742: Which enzyme is responsible for elongating the DNA strand? _____

Answer: DNA polymerase (specifically, DNA polymerase III in prokaryotes)

Flashcard 743: Elastin is tropoelastin with _____ scaffolding

Answer: fibrillin

Flashcard 744: The closer the recombination frequency is to _____%, the closer alleles in a haplotype are to each other

Answer: 0

Flashcard 745: There is an increased risk of autosomal recessive diseases in _____ families

Answer: consanguineous

Flashcard 746: DNA replication errors lead to _____ mutations

Answer: mismatch base

Flashcard 747: Hemoglobin C disease is caused by a mutation in the _____ chain of hemoglobin

Answer: Beta (β) globin

Extra: Hemoglobin C (HbC) is caused by a missense mutation in the **β-globin** gene, resulting in the substitution of **glutamic acid** with **lysine** at position 6 (Glu6Lys). Mnemonic: Ly**C**ine for Hb**C**; **V**al**S**ine for Hb**S**.

Flashcard 748: Mutation in the sonic hedgehog gene can cause _____

Answer: holoprosencephaly (specific/head)

Flashcard 749: If a male has an X-linked recessive disease, all of his daughters will be _____

Answer: carriers

Flashcard 750: What form of chromatin is highly condensed? _____

Answer: Heterochromatin