Metabolism — Flashcards

A study is being performed that includes certain men -Further analysis shows that these men have an X-linked mutation affecting the phosphoribosyl pyrophosphate (PRPP) synthetase gene. -This lead to increased substrate conversion. -What organ is most likely to develop pathology secondary to this mutation?

A 27 y/o woman has acute appendicitis. unable to eat. - Lab: moderate ketones in urine, borderline low serum glucose. -Based on evaluation, it's suspected that this patient is utilizing ketone bodies for energy. -What tissues cannot use this energy source?

What are the followings are associated with? -Ascorbic acid -Carnitine -Pyridoxine -Thiamine -Tyrosine -Vitamin K

24 y/o man comes with episodic enemia, jaundice, & dark urine. -These episodes typically occur after use of certain drugs or following infection. -History: brother has similar episodes. -Peripheral blood smear: shows RBC in image below. Deficiency of what enzyme would most likely result in a condition similar to this patient's presentation?

18 y/o girl with type 1 DM comes with several hours of nausea, vomiting and abominal pain. -breath: fruity odor -Glucose: 452 & high anion gap metabolic acidosis. -Increased activity of what enzyme is most likely contributing to this patient's abnormal blood glucose finding?

What are these two end-product has in common? -Sorbitol -galacticol

What are the symtoms of deficiency of the following vitamins and substances? -Ascorbic acid -Biotin -Linoleic acid -vitamin K -Zink

What are the followings are associated with? -Heme oxygenase -Biliverdin reductase

A 36 y/o man comes with dark urine and back pain. -patient ate some large, flat beans brought home by his wife after a business trip to egypt. -Physical exam: Jaundice & pallor. -Labs: hemoglobin 8g/dL. -Further evaluation reveals deficiency of an enzyme involved in the conversion of glucose-6-phosphate to ribulose-5-phosphate. -The substance generated during this conversion is necessary for which biochemical processes?

In between those 2 enzymes, which one of them is most likely will be inhibited in order to treat Acute intermittent porphyria? a.) ALA synthase b.) ALA deaminase