Metabolism — Flashcards

Flashcard 1421: The insulin-like growth factor (IGF) receptor has _____ activity, similar to the insulin receptor

Answer: tyrosine kinase

Flashcard 1422: Gamma-glutamyl transpeptidase (GGT) is associated with _____ use

Answer: alcohol

Flashcard 1423: Synthesis of GABA from glutamate requires _____ as a cofactor

Answer: vitamin B6

Flashcard 1424: Citrate synthase is regulated via negative feedback by _____

Answer: ATP

Flashcard 1425: Dietary vitamin B12 is complexed to animal-derived _____

Answer: proteins

Flashcard 1426: Activated vitamin K acts as a co-factor for the enzyme _____

Answer: Gamma-glutamyl carboxylase (γ-glutamyl carboxylase)

Flashcard 1427: Which neurotransmitter(s) are broken down by monoamine oxidase A (MAO-A)? _____

Answer: Serotonin, norepinephrine, and dopamine

Flashcard 1428: The **Amyloid Precursor Protein (APP)** on neurons is broken down by **\_\_\_\_\_ cleavage**, resulting in the formation of **A$\beta$ amyloid** particles.

Answer: $\beta$ (beta) cleavage

Extra: APP is normally cleaved by $\alpha$-secretase (non-amyloidogenic). Cleavage by $\beta$-secretase followed by $\gamma$-secretase results in the production of A$\beta$ (amyloid beta) peptides, which aggregate to form the plaques seen in Alzheimer's disease.

Flashcard 1429: D-dimers are derived from splitting of _____

Answer: cross-linked fibrin

Flashcard 1430: Does electron transport continue with electron transport inhibitors (e.g. CO, CN)? _____

Answer: No