Metabolism — Flashcards

Flashcard 1371: The glycoprotein thyroglobulin (TG) contains large quantities of the amino acid _____

Answer: tyrosine

Flashcard 1372: One type of receptor tyrosine kinase is a _____, which auto-phosphorylates upon binding of a hormone or ligand

Answer: dimer

Flashcard 1373: What do the carrier molecules NADH, NADPH, and FADH2 carry in their activated forms? _____

Answer: Electrons

Flashcard 1374: Neuronal death in Huntington disease occurs via NMDA-R binding and _____ excitotoxicity

Answer: glutamate

Flashcard 1375: Vitamin B12 deficiency takes _____ to develop due to large hepatic stores

Answer: years

Flashcard 1376: In adenosine deaminase (ADA) deficiency, _____ accumulates to toxic levels in lymphocytes

Answer: dATP

Flashcard 1377: 2,4-dinitrophenol is an _____ of oxidative phosphorylation

Answer: uncoupling agent

Flashcard 1378: Does the metabolism of **cationic** amino acids (e.g., lysine, arginine) cause a change in blood pH? _____

Answer: Yes (decreased)

Extra: The metabolism of **cationic** amino acids (Arginine, Lysine, Histidine) and **sulfur-containing** amino acids (Methionine, Cysteine) results in the net production of fixed acids (H+), which decreases blood pH. Conversely, the metabolism of **anionic** amino acids (Glutamate, Aspartate) and other organic anions (like citrate or lactate) consumes H+, which increases blood pH.

Flashcard 1379: The pK of the HCO3-/CO2 buffer is _____

Answer: 6.1

Flashcard 1380: Serum _____ is a reflection of iron stores in macrophages and the liver

Answer: ferritin