Metabolism — Flashcards

Flashcard 1211: Following binding of insulin receptor substrate 1 to the insulin receptor, _____-domain proteins bind to IRS-1

Answer: SH2

Flashcard 1212: Malate is converted to _____ via the enzyme malate dehydrogenase

Answer: oxaloacetate

Flashcard 1213: What is the shared structural feature of amyloid?

Answer: Beta-pleated sheet

Extra: All amyloid deposits, regardless of the precursor protein, share a common **cross-beta-pleated sheet** secondary structure. This structural feature is responsible for the characteristic apple-green birefringence when viewed under polarized light after staining with Congo red.

Flashcard 1214: One type of receptor tyrosine kinase is a _____, which dimerizes and auto-phosphorylates upon binding of a hormone or ligand

Answer: monomer

Flashcard 1215: What three steps does thyroid peroxidase catalyze during the synthesis of thyroid hormones?_____

Answer: 1. Oxidation (I- to I2) 2. Organification (of I2 into MIT and DIT) 3. Coupling (of MIT and DIT into T3 and T4)

Flashcard 1216: Factor XI of the coagulation cascade is activated by factor _____

Answer: XIIa

Flashcard 1217: In which organ does ketogenesis occur?_____

Answer: Liver

Flashcard 1218: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disorder resulting in reduced _____ of G6PD

Answer: half-life

Flashcard 1219: If G for a reaction is _____ than zero, energy must be added for the reaction to occur

Answer: greater

Flashcard 1220: What is the most abundant protein in the human body?_____

Answer: Collagen