Disorders of glycolytic enzymes — Flashcards

Flashcard 1: Pyruvate kinase defiency results in increased levels of _____, which causes decreased Hb affinity for O2

Answer: 2,3-BPG

Flashcard 2: What glycolysis enzyme deficiency causes hemolytic anemia in a newborn?_____

Answer: Pyruvate kinase deficiency

Flashcard 3: What is the only metabolic pathway for generating ATP, anaerobically? _____

Answer: Glycolysis

Flashcard 4: Pyruvate kinase is regulated via positive feedback by _____ (glycolysis)

Answer: fructose-1,6-bisphosphate

Flashcard 5: What is the rate-limiting enzyme of glycolysis?_____

Answer: Phosphofructokinase-1 (PFK-1)

Flashcard 6: phosphofructokinase-2/fructose bisphosphatase-2 (PFK-2/FBP-2)

Answer:

Extra: balances glycolysis and gluconeogenesisF-2,6-BP

Flashcard 7: Where does glycolysis take place?

Answer: cytoplasm

Flashcard 8: glycolysis

Answer: phosphofructokinase-1 (PFK-1)

Flashcard 9: What enzyme converts pyruvate to lactate?

Answer: lactate dehydrogenase (LDH)

Flashcard 10: glucokinase

Answer: first step of glycolysis and glycogen synthesis

Extra: tag glucose with phosphate so that it is trapped within the cellglucoseG6Pinsulinliver and β cells of pancreas