DNA repair US Medical PG Flashcards - Medical Study Cards
Master DNA repair with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
DNA repair Flashcard Deck - 10 Cards
Flashcard 11: Mechanisms to repair _____ breaks are defective in Ataxia telangiectasia, Fanconi anemia, and SCID
Answer: dsDNA
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-mutations-damage-and-repair?index=4]
https://onlinemeded.org/spa/immunology?ref=anki
Flashcard 12: Nonhomologous End Joining (NHEJ) occurs _____ S phase of the cell cycle
Answer: before
Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-mutations-damage-and-repair?index=6]
https://onlinemeded.org?ref=anki
Flashcard 13: Is Nonhomologous End Joining error prone?
_____
Answer: Yes
Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-mutations-damage-and-repair?index=6]
https://onlinemeded.org?ref=anki
Flashcard 14: DNA polymerase pauses and checks ("proof-reads") via _____ activity
Answer: 3' -> 5' exonuclease
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-replication-transcription-and-translation?index=2]
https://onlinemeded.org?ref=anki
Flashcard 15: Which base excision repair enzymes are responsible for filling and sealing the gap from the excised bases?
_____ (filling) and _____ (sealing)
Answer: DNA polymerase-β
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-mutations-damage-and-repair?index=3]
https://onlinemeded.org?ref=anki
Flashcard 16: What form of DNA repair fixes mutations due to spontaneous/toxic deamination?
_____
Answer: Base excision repair
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-mutations-damage-and-repair?index=3]
https://onlinemeded.org?ref=anki
Flashcard 17: _____ results from lack of excision endonuclease activity to remove pyrimidine dimers
Answer: Xeroderma pigmentosum
Extra:
https://onlinemeded.org?ref=anki
Flashcard 18: In Homologous Recombination, dsDNA breaks are recognized by the ATM protein and the FA Core Complex, which activate _____ to recruit enzymes to repair the break
Answer: BRCA1/2
Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-mutations-damage-and-repair?index=6]
https://onlinemeded.org?ref=anki
Flashcard 19: If DNA repair is not possible, p53 induces _____
Answer: apoptosis
Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/principles-of-oncology-and-therapeutics?index=10]
https://onlinemeded.org/spa/inflammation-and-neoplasia/apoptosis/acquire?ref=anki
Flashcard 20: Which base excision repair enzyme is responsible for removing nucleotides at the 5' end?
_____
Answer: AP-endonuclease
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-mutations-damage-and-repair?index=3]
https://onlinemeded.org?ref=anki
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