Cancer susceptibility and DNA repair — Flashcards

Flashcard 1: Nonhomologous End Joining (NHEJ) occurs _____ S phase of the cell cycle

Answer: before (before/after?)

Flashcard 2: What phase of the cell cycle do nucleotide excision repairs occur?_____

Answer: G1

Flashcard 3: Xeroderma Pigmentosum is an inherited pathology due to a defective _____ pathway

Answer: Nucleotide Excision Repair

Flashcard 4: When using CRISPR/Cas9 that introduce a double strand break to knock-out target DNA, _____ repair the gap introduced by this Cas9 variant

Answer: nonhomologous end joining enzymes

Flashcard 5: What form of DNA repair fixes mutations induced by UV radiation?_____

Answer: nucleotide excision repair

Flashcard 6: What process is used by mismatch repair enzymes to distinguish between old and new DNA strands in prokaryotes?_____

Answer: DNA methylation

Flashcard 7: What form of DNA repair fixes mutations due to DNA replication errors?_____

Answer: mismatch repair

Flashcard 8: Which base excision repair enzyme is responsible for removing nucleotides at the 5' end?_____

Answer: AP-endonuclease

Flashcard 9: What are the four mechanisms of DNA repair?

Answer: Nuceotide excision repair Base excision repair Mismatch repair Nonhomologous end joining

Flashcard 10: non-homologous end joining

Answer: join 2 dsDNA ends

Extra: double-stranded breaks (when no homologous chromosome is around to use as a guide)ataxia telangiectasia