General Surgery UK Medical PG Flashcards - Medical Study Cards
Master General Surgery with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
General Surgery Flashcard Deck - 10 Cards
Flashcard 411: Ticagrelor works by _____ which stops platelet activation and aggregation
Answer: reversibly blocking the P2Y12 ADP receptor
Flashcard 412: Aspirin works by _____ inhibiting COX-1
Answer: irreversibly
Extra: Aspirin acetylates the active site of COX-1, leading to irreversible inhibition. Since platelets cannot synthesize new proteins, the effect lasts for the lifetime of the platelet (approx. 7–10 days).
Flashcard 413: What is the mechanism of action for fondaparinux?
_____
Answer: Indirect inhibition of Xa via activation of antithrombin III
Flashcard 414: If clopidogrel must be stopped for surgery, it should be stopped _____ prior
Answer: 7 days
Flashcard 415: Patients taking DOACs who are undergoing surgery may need to pause their medication earlier if there is _____ impairment
Answer: renal
Flashcard 416: If aspirin must be stopped for surgery, it should be stopped _____ prior
Answer: 7 days
Flashcard 417: Clopidogrel works by inhibiting _____ which stops platelet activation and aggregation
Answer: ADP binding to P2Y12 receptor
Flashcard 418: Prasugrel works by _____ which stops platelet activation and aggregation
Answer: irreversibly blocking the P2Y12 ADP receptor
Flashcard 419:
DOACs can be restarted _____ after surgery
Answer: 12-24 hours
Extra: For procedures with low bleeding risk, DOACs are typically restarted 24 hours post-operatively. For high bleeding risk procedures, consider delaying 48-72 hours.
Flashcard 420: Unfractionated heparin should be stopped _____ prior to surgery
Answer: 6 hours
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