Severe Mental Illness — Flashcards

Flashcard 81: _____-onset familial Alzheimer's can be caused by PSEN1, PSEN2, & APP genes

Answer: Early

Flashcard 82: NICE recommend the use of cognitive testing tools for dementia, including _____ or the 6-item cognitive impairment test (6CIT)

Answer: 10-point cognitive screener (10-CS)

Flashcard 83: The most common type of dementia is _____

Answer: Alzheimer's

Flashcard 84: The leading cause of death in Alzheimer's is _____

Answer: aspiration pneumonia (caused by poor swallow)

Flashcard 85: The primary types of dementia include: _____ (up to 70%) Vascular dementia (up to 15%) Dementia with Lewy bodies (up to 10%) Frontotemporal dementia (up to 2%)

Answer: Alzheimer's disease

Flashcard 86: The ε2 allele of apolipoprotein E is associated with _____ risk for Alzheimer disease

Answer: decreased

Flashcard 87: The _____ lobe is first effected in Alzheimer's

Answer: medial temporal

Flashcard 88: After a blood screen, what other investigation may be used for dementia? _____

Answer: CT/MRI neuroimaging to exclude other reversible conditions

Flashcard 89: A mini-mental state exam (MMSE) score: _____ = normal 21-24 = mild cognitive impairment 10-20 = moderate cognitive impairment 0-9 = severe cognitive impairment

Answer: 25-30

Extra: The Mini-Mental State Examination (MMSE) is a 30-point questionnaire used extensively in clinical and research settings to measure cognitive impairment. It is commonly used in medicine and allied health to screen for dementia. Scores may need to be adjusted for education and age. The thresholds provided (e.g., <24 for impairment) are standard clinical benchmarks.

Flashcard 90: The ε4 allele of apolipoprotein E is associated with _____ risk for Alzheimer disease

Answer: increased