Rheumatology & Haematology — Flashcards

Flashcard 661: NHL may arise from which cell types? _____, T lymphocyte, NK cell

Answer: B lymphocyte

Flashcard 662: Hodgkin's lymphoma generally has a _____ prognosis

Answer: good

Flashcard 663: There are more than _____ types of Non-Hodgkin's lymphoma which can be broadly categorised into low-grade and high-grade

Answer: 60

Flashcard 664: The spread of Hodgkin's lymphoma is _____ between LN groups

Answer: continuous

Flashcard 665: What is the main side effect of Doxorubicin (chemo)? _____

Answer: Irreversible congestive heart failure (dilated cardiomyopathy) and red urine

Extra: Doxorubicin causes Type I cardiotoxicity: Dose-dependent, oxidative damage-mediated, and irreversible. Compare with Trastuzumab (Type II), which is typically reversible.

Flashcard 666: Osteolytic lesions caused by myeloma typically occur in the _____

Answer: skull & vertebrae

Flashcard 667: Which lymphoma classically presents with a bimodal age distribution, often affecting younger patients? \n_____

Answer: Hodgkin's lymphoma

Extra: Hodgkin Lymphoma typically shows a **bimodal age distribution**, with the first peak in young adults (ages 15–35) and a second peak in older adults (>55 years). In contrast, most Non-Hodgkin Lymphomas increase in incidence steadily with age.

Flashcard 668: Induction therapy prior to stem cell transplantation in myeloma involves a combination of: 1. _____ 2. Chemotherapy (e.g. cyclophosphamide) 3. Steroids (e.g. dexamethasone)

Answer: Targeted immunomodulatory drugs (e.g. thalidomide or bortezomib)

Flashcard 669: Patients may take _____ following stem cell transplantation for myeloma in the form of lenalidomide

Answer: maintenance therapy

Flashcard 670: _____ lymphoma is much more common

Answer: Non-Hodgkin's