Rheumatology & Haematology — Flashcards

Flashcard 641: What is the main side effect of _____? Acute pancreatitis

Answer: L-asparaginase

Extra: L-asparaginase depletes serum asparagine, inhibiting protein synthesis. Key side effects: 1. **Acute Pancreatitis** (classic Boards association) 2. **Thrombosis** (due to depletion of Antithrombin III, Protein C, and S) 3. **Hypersensitivity/Anaphylaxis** 4. **Hyperglycemia** (decreased insulin synthesis)

Flashcard 642: _____ lymphoma is associated with translocation of the MYC oncogene

Answer: Burkitt

Flashcard 643: Lymphoma is staged using the Ann Arbor staging system: Stage 1: _____ Stage 2: ≥2 lymph node regions on the same side of the diaphragm Stage 3: Lymph node regions on both sides of the diaphragm (may include extralymphatic involvement) Stage 4: Diffuse extralymphatic disease A - B symptoms absent B - With B symptoms E - Extra-nodal site involved X - Bulky disease

Answer: Single lymph node region or extralymphatic site

Flashcard 644: What is the 1st line managment of Hodgkin's lymphoma? _____

Answer: Chemotherapy (ABVD)

Flashcard 645: What are the diagnostic investigations for NHL? _____, Immunophenotyping

Answer: LN excision biopsy

Flashcard 646: Which type of lymphoma has the greatest association with _____? Answer: Burkitt's lymphoma

Answer: EBV

Flashcard 647: A typical FBC in a patient with NHL will show _____, thrombocytopenia, neutropenia, lymphocytosis

Answer: anaemia

Flashcard 648: The spread of Non-Hodgkin's lymphoma is _____ between LN groups

Answer: discontinuous

Flashcard 649: _____ lymphoma is associated with malaria infection

Answer: Burkitt's

Flashcard 650: All patients with NHL should be tested for _____

Answer: HIV