Rheumatology & Haematology — Flashcards

Flashcard 461: How are infections prevented in SLE? _____

Answer: Vaccinate! Offer influenza & pneumococcal vaccinations

Flashcard 462: Which antibody correlates with disease activity & lupus nephritis activity in SLE? _____

Answer: anti-dsDNA

Flashcard 463: SLE is associated with hyper_____ states

Answer: oestrogenic

Flashcard 464: The characteristics of systemic lupus erythematosus (SLE) may be remembered with the mnemonic _____

Answer: RASH OR PAIN

Extra: The mnemonic **RASH OR PAIN** for SLE criteria: - **R**ash (Malar) - **A**rthritis - **S**erositis - **H**ematologic disorders (anemia, leukopenia) - **O**ral ulcers - **R**enal disease - **P**hotosensitivity - **A**ntinuclear antibody (ANA) - **I**mmunologic markers (Anti-dsDNA, Anti-Sm, etc.) - **N**eurological disorders (seizures, psychosis)

Flashcard 465: Which antibody is sensitive, but not specific for SLE? _____

Answer: Antinuclear antibodies (ANA)

Flashcard 466: SLE affects _____ 10:1 typically of child-bearing age

Answer: females

Flashcard 467: SLE has accelerated _____ that is the most common cause of death

Answer: atherosclerosis

Flashcard 468: Diffuse proliferative glomerulonephritis (DPGN) is a common cause of death in patients with _____

Answer: SLE

Flashcard 469: What HLA subtypes are associated with SLE? _____

Answer: HLA-DR2 & HLA-DR3

Flashcard 470: Which antibodies are specific, but not sensitive for SLE? _____

Answer: anti-dsDNA and anti-Smith antibodies