Rheumatology & Haematology — Flashcards

Flashcard 411: Chronic myeloid leukaemia is often diagnosed _____ on a FBC

Answer: incidentally

Flashcard 412: Polycythaemia vera is a form of _____ polycythemia

Answer: primary

Flashcard 413: The t(9;22) translocation (BCR-ABL) is also known as the _____ chromosome most commonly seen in chronic myeloid leukaemia (CML)

Answer: Philadelphia

Flashcard 414: What is the most common cause of morbidity in polycythaemia vera? _____

Answer: Thrombosis

Flashcard 415: Secondary polycythemia (due to hypoxemia) is characterized by _____ SaO2 percentage.

Answer: decreased

Extra: Other causes of secondary polycythemia (like EPO-secreting tumors) may have normal SaO2 but elevated EPO.

Flashcard 416: ↑ Hb ↑ Haematocrit with ↓ EPO normal O2 sats = _____ ↑ Hb ↑ Haematocrit with ↑ EPO & ↓ O2 sats = secondary polycythaemia

Answer: Primary polycythaemia (polycythaemia vera)

Flashcard 417: Accelerated phase of CML presents with fatigue because of _____

Answer: anaemia

Flashcard 418: Chronic myeloid leukaemia is a _____ disorder

Answer: myeloproliferative

Flashcard 419: What are the examination finding(s) of chronic myeloid leukaemia? _____

Answer: Massive splenomegaly (larger as the phases progress)

Flashcard 420: Polycythaemia vera has a mutation of the _____ gene that ↑ tyrosine kinase activity causing EPO-independent erythrocytosis

Answer: JAK2