Rheumatology & Haematology — Flashcards

Flashcard 281: Disseminated intravascular coagulation (DIC) is associated with bleeding, especially from _____ sites & mucosal surfaces

Answer: IV

Flashcard 282: Disseminated intravascular coagulation (DIC) may occur secondary to sepsis, especially gram _____ bacteria

Answer: -ve

Flashcard 283: Severe sepsis (gram -ve bacteria), trauma & burns, obstetric complications, malignancy (APL), major surgery are all causes of _____

Answer: disseminated intravascular coagulation (DIC)

Flashcard 284: How do platelet levels change post-splenectomy? _____

Answer: Increased (thrombocytosis)

Flashcard 285: What are the initial investigations for suspected disseminated intravascular coagulation (DIC)? _____

Answer: Coagulation studies (aPTT, PT, fibrinogen, D-dimer) & FBC (platelets)

Flashcard 286: The antibiotic prophylactic medication of choice for splenectomy/hyposplenic patients is _____.

Answer: Phenoxymethylpenicillin (penicillin V)

Extra: Post-splenectomy patients are at high risk for Overwhelming Post-Splenectomy Infection (OPSI), primarily from encapsulated organisms (S. pneumoniae, H. influenzae, N. meningitidis). Daily prophylaxis with Penicillin V is recommended, especially for the first 2 years post-surgery or in children.

Flashcard 287: Acute myeloid leukemia can cause _____ because of suppression of thrombocytopoiesis

Answer: bleeding/bruising

Flashcard 288: Acute myeloid leukemia can cause _____ because of suppression of erythropoiesis

Answer: fatigue

Flashcard 289: Acute myeloid leukaemia may arise from pre-existing _____ syndromes & myeloproliferative disorders

Answer: myelodysplastic

Flashcard 290: Leukaemic cells can infiltrate the skin resulting in leukaemia cutis particularly in acute _____ leukaemia

Answer: myeloid