Rheumatology & Haematology — Flashcards

_____ commonly causes aplastic crisis in patients with sickle cell disease because of temporary suppression of erythropoiesis

Vaso-occlusive crisis is _____ of tissue secondary to microvascular occlusion from sickled RBCs

The sickle cell allele / HbS provides protection against _____, which likely explains the high prevalence in Africans

Sickle cell disease can be complicated with _____ from encapsulated organisms causing sepsis, pneumonia, & meningitis

What is the likely diagnosis in an African American infant that presents with symmetric swelling/tenderness of the bilateral hands and feet? _____

Hint: diagnosis?

Sickle cell disease will likely cause chronic _____ presenting with persistent fatigue, pallor, & delayed growth in children

Suspect _____ in patients with sickle cell disease that have LUQ tenderness, hypovolaemic shock, & splenomegaly

_____ in sickle cell disease is accelerated destruction of sickled RBC leading to worsening anaemia, jaundice, & ↑ bilirubin

What are the major causes of acute severe anaemia in sickle cell disease? _____: ↓ reticulocyte count + no splenomegaly Splenic sequestration (Vaso-occlusion): ↑ reticulocyte count + splenomegaly

What is the initial general management for vaso-occlusive crisis/events? _____