Rheumatology & Haematology — Flashcards

What is the likely diagnosis in an African American infant that presents with symmetric swelling/tenderness of the bilateral hands and feet? _____

Hint: diagnosis?

Acute chest syndrome in patients with sickle cell disease is often precipitated by _____

Vaso-occlusive crisis is _____ of tissue secondary to microvascular occlusion from sickled RBCs

Sickle cell disease can cause _____ that involves splenic vaso-occlusion and pooling of large amounts of blood in the spleen

Suspect _____ in patients with sickle cell disease that have LUQ tenderness, hypovolaemic shock, & splenomegaly

What is the most common acute complication/event in sickle cell disease? _____

_____ is a possible feature of sickle cell disease that involves acute & reversible reticulocytopaenia

What are the major causes of acute severe anaemia in sickle cell disease? _____: ↓ reticulocyte count + no splenomegaly Splenic sequestration (Vaso-occlusion): ↑ reticulocyte count + splenomegaly

Sickle cell disease can be complicated with _____ from encapsulated organisms causing sepsis, pneumonia, & meningitis

_____ in sickle cell disease is accelerated destruction of sickled RBC leading to worsening anaemia, jaundice, & ↑ bilirubin