Rheumatology & Haematology — Flashcards

Suspect _____ in patients with sickle cell disease that have chest pain, fever, dyspnoea, & lung infiltrates

What are the major causes of acute severe anaemia in sickle cell disease? _____: ↓ reticulocyte count + no splenomegaly Splenic sequestration (Vaso-occlusion): ↑ reticulocyte count + splenomegaly

Sickle cell disease can cause _____ that involves splenic vaso-occlusion and pooling of large amounts of blood in the spleen

One consequence of autosplenectomy in sickle cell disease is increased risk of infection with _____ organisms

Sickle cell disease can be complicated with _____ from encapsulated organisms causing sepsis, pneumonia, & meningitis

In sickle cell disease antibiotic prophylaxis with _____ is given at ages >3months until 5 years old (or lifelong)

Sickle cell disease can present as _____ in the male sex organ

Newborn babies are screened for sickle cell disease on _____ with the newborn blood spot screening programme (heel prick test)

Hint: timing

Sickle cell trait presents _____, unless in severe conditions

Sickle cell anaemia has _____ reticulocyte count

Hint: ↓/↑