Gastroenterology & Hepatology — Flashcards

Flashcard 481: Chronic hepatitis C can be complicated with _____ which can lead to hepatocellular carcinoma

Answer: cirrhosis

Flashcard 482: If an outbreak of hepatitis A is suspected or the patient is a food handler, then _____

Answer: notify the local Health Protection Unit promptly

Flashcard 483: _____ is a self-limiting infection with hepatitis A virus that causes inflammation of the liver

Answer: Hepatitis A

Flashcard 484: LFTs for hepatitis A will show: _____ ALT & AST Normal or ↑ bilirubin Normal or ↑ PT

Answer: Significantly ↑

Flashcard 485: Hepatitis B serology: HbsAg _____ Anti-HBs -ve Anti-HBc IgG +ve = Chronic hepatitis B

Answer: +ve

Flashcard 486: Complications of chronic hepatitis B include _____ which can progress into hepatocellular carcinoma

Answer: cirrhosis

Flashcard 487: Hepatitis A serology with -ve HAV-IgM & +ve HAV-IgG indicates _____ or immunity

Answer: past hepatitis A infection

Flashcard 488: What are the primary serologic tests for Hepatitis A diagnosis? Acute infection = _____ Past infection/Immunity = Anti-HAV IgG

Answer: Anti-HAV IgM

Extra: Hepatitis A is a self-limiting viral infection transmitted via the fecal-oral route. Serology is the primary method of diagnosis: - **Anti-HAV IgM**: Detectable at the onset of symptoms, peaks early, and disappears within 3-6 months. Indicates **acute infection**. - **Anti-HAV IgG**: Appears shortly after IgM and persists for life, providing immunity. Indicates **past infection or vaccination**. - **HAV RNA (PCR)**: Can detect the virus in blood/stool before IgM appears, but is not standard clinical practice.

Flashcard 489: What is the mainstay management of Hepatitis A? _____

Answer: Symptomatic treatment Admit to hospital if necessary

Flashcard 490: Patients with hepatitis A should excluded from work, school, or nursery _____ after onset of jaundice or 7 days after symptom onset if no history of jaundice

Answer: 7 days