Clinical Pharmacology and Drug Toxicity — Flashcards

Adverse effects of sirolimus (rapamycin) include _____ and insulin resistance

_____ inhibits the enzyme acetaldehyde dehydrogenase

Cyclophosphamide can cause a congenital syndrome (remember with the mnemonic conGEAL) - congenital: _____, Ear and facial abnormalities, Absence of digits, Limb hypoplasia

Hint: G

Chimeric monoclonal antibodies can sometimes cause a(n) _____ within 7-10 days of administration

_____ targets the CD3 protein on T cells and is used for acute organ rejection

There is increased risk of progressive multifocal leukoencephalopathy in patients taking _____ and rituximab

Idiopathic intracranial hypertension can be associated with use of certain drugs, such as _____ and danazol

Polymyxins are severely toxic against the _____ and kidneys

Aminoglycosides are known to be both _____-toxic and nephro-toxic

Tocilizumab is an anti-_____ monoclonal antibody indicated for Giant Cell Arteritis and Cytokine Release Syndrome