Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 361: Bullous eruptions is one of the manifestations of _____ drug poisoning

Answer: barbiturate

Flashcard 362: Propofol infusion syndrome presents with _____ leading to hyperkalemia

Answer: rhabdomyolysis

Flashcard 363: Morphine use is contraindicated in _____ failure

Answer: renal

Flashcard 364: _____ is avoided in post-chemotherapy patients as it can cause bone marrow suppression

Answer: Linezolid (Antibiotic)

Flashcard 365: ADH secretion is decreased in SIADH by _____.

Answer: phenytoin (anti-epileptic drug)

Flashcard 366: _____ is the most common cause of drug related hypercalcemia.

Answer: Thiazide diuretics

Extra: Lithium is the second most common cause of drug-induced hypercalcemia. While Lithium has a higher incidence of hypercalcemia among users (up to 25%), Thiazide diuretics are much more commonly prescribed, making them the most frequent drug-related cause encountered in clinical practice.

Flashcard 367: What is the investigation of choice for diagnosing acute lithium toxicity?_____

Answer: Serum Lithium levels

Flashcard 368: Sugammadex is a selective relaxant binding agent used to reverse the effects of which class of neuromuscular blockers?

Answer: Aminosteroids (specifically Rocuronium and Vecuronium)

Extra: Sugammadex works by encapsulating (chelating) the drug molecules in a 1:1 ratio. **It is effective against:** * Aminosteroids (Rocuronium > Vecuronium >> Pancuronium) **It is NOT effective against:** * Benzylisoquinolines (e.g., Atracurium, Cisatracurium, Mivacurium) * Depolarizing agents (Succinylcholine)

Flashcard 369: Excess of _____ causes alkali disease in livestock.

Answer: selenium

Flashcard 370: Among the **oral** forms of nicotine replacement therapy (NRT), nicotine _____ offer the highest level of nicotine delivery.

Answer: lozenges