Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 291: Which drug used for lepra reaction is associated with "drug-induced lipofuscinosis"?_____

Answer: Clofazimine

Flashcard 292: Which poisoning results in a **left shift** of the oxygen-hemoglobin dissociation curve and a **decreased oxygen-carrying capacity**?

Answer: Carbon monoxide poisoning

Flashcard 293: Cardiotoxicity due to bupivacaine usually manifests as cardiovascular _____

Answer: depression

Flashcard 294: _____ toxicity can cause bull s eye maculopathy.

Answer: Hydroxychloroquine

Flashcard 295: In nephrotic syndrome, the effect of Warfarin is _____

Answer: reduced

Flashcard 296: Cicuta maculata (water hemlock) is a ____

Answer: Convulsant (GABA-A antagonist)

Flashcard 297: Is 2-naphthylamine a direct or indirect acting carcinogen?

Answer: Indirectly acting carcinogen (procarcinogen)

Extra: 2-naphthylamine is a procarcinogen classically associated with bladder cancer (urothelial carcinoma). It requires metabolic activation (specifically N-hydroxylation in the liver) to form its active carcinogenic metabolite.

Flashcard 298: Which drug useful in gout increases the risk of MI and stroke?_____

Answer: Febuxostat

Flashcard 299: Which phase of clinical trials involves patients with target disease?_____

Answer: Phase II and III

Flashcard 300: Which **fluoroquinolone** has the highest risk for QT interval prolongation and torsades de pointes?

Answer: Moxifloxacin