Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 231: Do Carbamates cause Intermediate syndrome?

Answer: No

Extra: Intermediate syndrome is characteristically associated with **Organophosphate** poisoning (occurring 24-96 hours after exposure). It is generally **not** seen with carbamate poisoning because carbamates are reversible inhibitors of acetylcholinesterase and have a shorter duration of action.

Flashcard 232: Is miosis a universal finding in opioid intoxication?_____

Answer: No

Flashcard 233: A patient having a hypersensitivity reaction to phenytoin warrants _____

Answer: discontinuation of phenytoin

Flashcard 234: Isopropyl alcohol is _____ toxic than methyl alcohol

Answer: less

Flashcard 235: _____ is associated with vestibular toxicity

Answer: Minocycline (Tetracycline)

Flashcard 236: Which antimalarial has a "black box" warning due to serious and permanent neuropsychiatric manifestations?_____

Answer: Mefloquine

Flashcard 237: Which phase of drug development does not require Good Clinical Practice (GCP)?

Answer: Preclinical phase (requires Good Laboratory Practice [GLP])

Flashcard 238: Which IV anesthetic is associated with hypertriglyceridemia and hence pancreatitis?_____

Answer: Propofol

Flashcard 239: Shellfish poisoning is due to the neurotoxin _____

Answer: Saxitoxin

Flashcard 240: Hyponatremia risk with oxcarbazepine is _____ when compared to carbamazepine

Answer: higher (higher/lower)