Central Nervous System Pharmacology — Flashcards

Flashcard 191: Opioids such as meperidine, tramadol, fentanyl and _____ block neuronal uptake of serotonin and can cause Serotonin syndrome

Answer: dextromethorphan

Flashcard 192: _____ is a selective H3 receptor inverse agonist used in the treatment of Narcolepsy.

Answer: Pitolisant

Extra: Pitolisant (formerly known as tiprolisant) is a selective H3-receptor inverse agonist. By blocking presynaptic H3 autoreceptors, it increases the synthesis and release of histamine, a wake-promoting neurotransmitter. It is used for the treatment of excessive daytime sleepiness (EDS) and cataplexy in patients with narcolepsy.

Flashcard 193: The best drug for long-term preventive therapy for SUNCT/SUNA is _____.

Answer: lamotrigine

Flashcard 194: Vigabatrin acts by irreversibly blocking the _____ to increase GABA action.

Answer: GABA transaminase

Flashcard 195: _____ is a 5-HT1F receptor agonist used for acute attacks of migraine and can be used in patients with CAD

Answer: Lasmiditan

Flashcard 196: Valproate is _____ used as a first line drug in the treatment of focal seizures with intact awareness

Answer: not

Flashcard 197: Drug of choice for absence seizures:

Answer: Ethosuximide

Flashcard 198: Drug of choice in drug induced parkinsonism is:

Answer: Anticholinergics

Flashcard 199: Drug of choice in acute severe migraine is:

Answer: Sumatriptan

Flashcard 200: Drug of choice in treatment of focal complex seizures

Answer: Carbamazepine