Antimicrobial Agents — Flashcards

Flashcard 241: The primary mode of resistance to fluoroquinolones is due to mutation in _____ or due to plasmid-mediated resistance

Answer: DNA gyrase

Flashcard 242: Which two anti-influenza drugs inhibit the M2 channels? _____

Answer: Amantadine and Rimantadine

Flashcard 243: Apart from Benzathine penicillin, treatment of syphilis can also be done with: _____ 500 mg qid for 14 days

Answer: Tetracycline or Erythromycin

Extra: Doxycycline (100 mg BID for 14 days) is currently the preferred oral alternative for penicillin-allergic patients with primary or secondary syphilis. Tetracycline (500 mg QID) and Erythromycin (500 mg QID) for 14-15 days are other alternatives.

Flashcard 244: _____ is a drug that works by blocking Plasmodium heme polymerase (enzyme)

Answer: Chloroquine

Flashcard 245: Which antibiotics bind divalent ions (Fe2+, Ca2+, and Mg2+) resulting in chelation?_____

Answer: Tetracyclines

Flashcard 246: Rifampicin _____ once a month + dapsone 100mg daily + clofazimine 300mg once a month and 50 mg daily is used to treat leprosy in adults and children older than 14 years

Answer: 600mg

Flashcard 247: Second generation cephalosporins have _____ activity against gram-positive bacteria when compared with first generation cephalosporins.

Answer: lesser

Flashcard 248: Intravenous _____ and/or quinidine is used for severe malaria infections

Answer: artesunate

Flashcard 249: For Malaria Chemoprophylaxis: Duration of travel is _____ than 6 weeks then mefloquine 250mg once a week can be started 2 weeks before travel and continued atleast 4 weeks after travel.

Answer: more

Flashcard 250: CMV can gain resistance to ganciclovir via mutations in the _____ gene or its DNA polymerase

Answer: UL-97