Topoisomerase Inhibitors — Flashcards

Anthracyclines (doxorubicin, daunorubicin) treat both _____ malignancies and solid tumors

Antineoplastic agents extracted from the _____ plant is: Vinca alkaloidsalso called Catharanthus roseus

Topotecan, a Topoisomerase I inhibitor, is used to treat cancers of the _____ system and small cell lung cancer

Etoposide and teniposide have activity against both _____ and solid tumor malignancies

Intercalation of Anthracyclines into DNA inhibits the progression of Topoisomerase II and induces eviction of histones

Anthracyclines (doxorubicin, daunorubicin) form _____ which cause breaks in DNA

Antineoplastic agents extracted from the Periwinkle plant is: _____ also called Catharanthus roseus

_____ is a drug of choice for mesothelioma.

Hint: Antifolate drug

Cetuximab is a monoclonal antibody against the _____ Receptor most commonly used to treat Stage IV colorectal cancer

_____ is a monoclonal antibody against PDGFR- and blocks ligand-mediated receptor activation