Anticancer Drugs — Flashcards

Flashcard 81: Trastuzumab works by binding _____, preventing it from dimerizing with the EGFR receptor

Answer: HER2/neu

Flashcard 82: _____ is a prodrug of 5-fluorouracil with similar activity

Answer: Capecitabine

Flashcard 83: The P-glycoprotein is an _____-dependent efflux pump that tumors can produce to generate chemotherapeutic resistance

Answer: ATP

Flashcard 84: _____ is an androgen receptor inhibitor indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer.

Answer: Apalutamide

Flashcard 85: Bifunctional alkylating agents usually transfer _____ groups to DNA, resulting in cross-linking.

Answer: alkyl

Extra: Alkylating agents most commonly attach an alkyl group to the N7 position of guanine. Bifunctional agents (e.g., nitrogen mustards, nitrosoureas, busulfan) have two reactive groups, allowing them to form DNA cross-links (interstrand or intrastrand).

Flashcard 86: Prostatic adenocarcinoma may be treated with _____ analogs (e.g. leuprolide) and/or androgen receptor inhibitors (e.g. flutamide)

Answer: GnRH

Flashcard 87: Bevacizumab has an increased risk of _____ and thrombotic events

Answer: bleeding

Flashcard 88: _____ is a small-molecule inhibitor of BCL-2

Answer: Venetoclax

Flashcard 89: Secondary mechanism of action of _____ is inhibition of AICAR transformylase

Answer: Methotrexate

Flashcard 90: Ifosfamide use can result in _____, with the bladder toxicity arising from the metabolite acrolein

Answer: hemorrhagic cystitis