Antimetabolites — Flashcards

As an antineoplastic, Methotrexate is primarily indicated for cancers of lymphocytes, particularly _____ and lymphomas

Cerebellar toxicity is seen with which anti-cancer drug?_____

_____ inhibits thymidylate synthase, which catalyzes conversion of dUMP to dTMP (pyrimidine synthesis)

_____ is an antimetabolite that inhibits pyrimidine synthesis inhibiting Ribonucleotide Reductase, thus blocking Thymidine synthesis

Drug of choice for Hairy cell leukemia

_____ is a prodrug of 5-fluorouracil with similar activity

Antineoplastic agents extracted from the Periwinkle plant is: _____ also called Catharanthus roseus

_____ is a drug of choice for mesothelioma.

Hint: Antifolate drug

Cetuximab is a monoclonal antibody against the _____ Receptor most commonly used to treat Stage IV colorectal cancer

_____ is a monoclonal antibody against PDGFR- and blocks ligand-mediated receptor activation