Neoplasia — Flashcards

Flashcard 31: _____ is a subtype of DCIS (breast) characterized by ducts filled with high-grade cells and central necrosis which often shows dystrophic calcification.

Answer: Comedocarcinoma

Extra: The term "comedo" refers to the necrotic debris which can be squeezed from the ducts like toothpaste or a comedone (blackhead) during gross examination.

Flashcard 32: MEN 1 is associated with mutation of the _____ gene (menin), which is a tumor suppressor gene found on chromosome 11

Answer: MEN1

Flashcard 33: Which four carcinomas route hematogenously?_____ChoriocarcinomaRenal cell carcinomaHepatocellular carcinoma

Answer: Follicular thyroid carcinoma

Flashcard 34: HPV encodes E6 and E7 which promotes proteolysis of _____ and Rb.

Answer: p53

Flashcard 35: The t(_____,14) translocation results in overexpression of Cyclin D1, which promotes the G1/S transition in the cell cycle, facilitating neoplastic proliferation

Answer: 11

Flashcard 36: _____ carcinoma of the lung may produce PTHrP leading to hyper-calcemia

Answer: Squamous cell

Flashcard 37: Most common _____ tumor of salivary gland in children is hemangioma

Answer: benign

Flashcard 38: Tumors that cause _____ can be remembered with the mnemonic "Potentially Really High Hematocrit Levels": - Pheochromocytoma - Renal cell carcinoma - Hepatocellular carcinoma - Hemangioblastoma - Leiomyoma

Answer: paraneoplastic polycythemia

Flashcard 39: Ovarian serous adenocarcinoma is CK 7 _____ and CK 20 negative

Answer: positive

Flashcard 40: Smooth muscle can give rise to a _____ (benign) and leiomyosarcoma (malignant)

Answer: leiomyoma