Neoplasia — Flashcards

_____ carcinoma of the lung is characterized by positive staining for chromogranin A, neuron-specific enolase, synaptophysin, and NCAM (CD56)

_____ is the malignant proliferation of cells in the lobules of the breast with no invasion of the basement membrane

_____ syndrome is a combination of: 1. Wilms tumor 2. Early-onset nephrotic syndrome 3. Male pseudohermaphroditism (gonadal dysgenesis)

Neurofibromatosis type I is associated with mutations in the _____ tumor suppressor gene on chromosome 17

2-Naphthylamine is a carcinogenic aromatic amine found in _____ associated with Transitional Cell Carcinoma of the Bladder

Wilms tumor is caused by "loss of function" mutations of tumor suppression genes _____ or WT2 on chromosome 11

_____ is a malignant salivary gland tumor composed of mucinous and squamous cells. It is most commonly associated with the t(11;19) translocation creating the CRTC1-MAML2 fusion protein.

_____ is a salivary gland tumor composed of chondromyxoid stroma and epithelium

ER/PR-_____, HER2-negative breast cancer is the most common subtype in individuals who inherit germline mutations in BRCA1

Chronic irritation of the bladder can cause _____ metaplasia, which may progress to squamous cell carcinoma