Neoplasia — Flashcards

The tumor suppressors encoded by the CDKN2A gene enforce the G1-->S restriction point by:(1) - inhibiting CDK_____/6 (2) - relieving inhibition of P53

_____ disease is an inherited disease associated with increased risk for renal cell carcinoma and hemangioblastoma of the cerebellum

Epithelial tumors that grow _____ are known as papillomas when benign and papillary carcinoma when malignant

Neurofibromatosis type I is associated with mutations in the _____ tumor suppressor gene on chromosome 17

Tumor staging is based on _____ (c) or pathological (p) findings

_____ molecular subtype is a triple-negative breast cancer with low expression of E-cadherin and a poor prognosis.

Metastasis oncogenes such as _____ and TWIST encode transcription factors whose primary function is to promote epithelial-to-mesenchymal transition (EMT).

_____ tumor is metastatic mucinous tumor that involves both ovaries; most commonly due to metastatic gastric carcinoma (diffuse type)

_____ syndrome is a combination of: 1. Wilms tumor 2. Early-onset nephrotic syndrome 3. Male pseudohermaphroditism (gonadal dysgenesis)

_____ is a malignant germ cell tumor composed of mononuclear cytotrophoblasts and multinuclear syncytiotrophoblasts, but with absent villi