Polymerase Chain Reaction Applications — Flashcards

In Array based Comparative Genomic Hybridization, if the test sample has deletion, then some spots on the array will flouresce _____

In Array based Comparative Genomic Hybridization, if the test sample has amplification, then some spots on the array will flouresce _____.

What is the mode of diagnosis of Duchenne muscular dystrophy?_____

Which molecular test for breast cancer can be used for both ER/PR positive and hormone-receptor negative cancers?_____

The presence of _____ mutation is associated with poor prognosis in chronic lymphocytic leukemia (CLL)

_____ syndrome is due to an inherited defect in DNA mismatch repair enzymes, resulting in microsatellite instability

_____ syndrome is most commonly characterized by a 47,XXY karyotype

_____ disease is due to a deletion of the VHL gene on chromosome 3p, leading unregulated activity of HIF1a

Mutations that cause _____ of the HER2 receptor can precipitate development of certain Breast* and Gastric* Cancers by amplifying the signal transduction

Over 85% of mutations in the FGFR3 gene occur _____ and are related to increased paternal age