Molecular Oncology — Flashcards

Abnormal tissue expression of the tumor-suppressor gene _____ is seen in the pterygium tissue

What is the mechanism that results in malignancy from the c-MYC oncogene?_____

What is the first cancer to be directly associated with genetic abnormality?_____

HER2-_____ cancers are most common subtype of breast cancer in patients with germline mutations in TP53 (Li Fraumeni syndrome)

_____ is a molecular test in breast cancer that is a 21-gene assay

What is the mechanism that results in malignancy from the cyclin D1 oncogene?_____

_____ syndrome is most commonly characterized by a 47,XXY karyotype

_____ disease is due to a deletion of the VHL gene on chromosome 3p, leading unregulated activity of HIF1a

Mutations that cause _____ of the HER2 receptor can precipitate development of certain Breast* and Gastric* Cancers by amplifying the signal transduction

Over 85% of mutations in the FGFR3 gene occur _____ and are related to increased paternal age