Liver and Biliary Pathology — Flashcards

Flashcard 21: _____ autoantibodies are associated with autoimmune hepatitis type 1

Answer: Anti-smooth muscle

Flashcard 22: Bartonella henselae can cause _____, characterized by cystic blood-filled spaces in the hepatic parenchyma

Answer: bacillary peliosis

Flashcard 23: _____ deficiency is characterized by pink/purple colored, PAS-positive, diastase-resistant globules in hepatocytes

Answer: Alpha-1 antitrypsin

Flashcard 24: Hepatocyte necrosis is characterized by _____ swelling and cytoplasmic emptying ("ballooning degeneration")

Answer: cellular

Flashcard 25: Cholangiocarcinoma is CK 7 _____ and CK 20 negative

Answer: positive

Extra: IHC Profiles for Liver Tumors: - **Cholangiocarcinoma:** CK7 (+), CK20 (-), CK19 (+) - **Hepatocellular Carcinoma:** CK7 (-), CK20 (-), HepPar-1 (+) - **Metastatic Colorectal Carcinoma:** CK7 (-), CK20 (+), CDX2 (+)

Flashcard 26: Cirrhosis is characterized by disruption of normal hepatic parenchyma by bands of _____ and regenerative nodules of hepatocytes

Answer: fibrosis

Flashcard 27: Hepatic _____ are rare, benign tumors associated with OCP and anabolic steroid use; regress upon cessation of drug

Answer: adenomas

Flashcard 28: Schistosoma _____ and japonicum can result in portal hypertension due to pipestem fibrosis

Answer: mansoni

Flashcard 29: _____ cholangitis causes periductal fibrosis with an 'onion-skin' appearance histologically

Answer: Primary sclerosing

Flashcard 30: _____ rise is seen in many liver diseases but more than fourfold rise indicates cholestasis.

Answer: Alkaline phosphatase