Autoimmune Diseases — Flashcards

_____ amyloidosis is characterized by systemic deposition of AA amyloid, which is derived from serum amyloid-associated protein (SAA)

Deficiency of _____ protein causes autoimmune polyendocrine syndrome-1

_____ are involved in the recognition and clearance of necrotic cells.

_____ is a IHC marker seen with Breast carcinoma, urothelial carcinoma, salivary duct carcinoma and choriocarcinoma

PTLD has a variety of symptoms; ranging from symptoms that resemble _____ to malignancy induced dysfunction of the transplanted organ

The most common antibodies associated with TRALI are those that bind particularly _____ antigens

_____ amyloidosis is characterized by systemic deposition of AL amyloid, which is derived from Ig light chain

Biopsy for IgG4 disease will demonstrate dense _____ infiltrate

LE cell is a phagocytic _____ or _____ that has engulfed the denatured nucleus of an injured cell

--- Do with heme --- Type II Hypersensitivity Disorders - Cytotoxic: Transfusion Reaction - Antibody against _____ - IgM isohemagglutinins formed naturally in response to bacterial flora cause opsonization and complement activation - Leads to hemolysis **Hemolytic Disease of the Newborn (Erythroblastosis fetalis) Antibody = _____ - Formed in _____ mother carrying _____ child - First pregnancy _____ (doesn't have to be viable pregnancy) - Antibody crosses placenta and injures subsequent fetuses - Prevent with _____ (anti-Rh, binds fetal red cells and prevents mothers immune system from reacting) ABO blood typing and screening for other preformed Abs; always done in case of transplants. Universal donor: type _____ Universal recipient: type _____ (Ex) Type A can donate to _____ and _____. Type A can receive donations from _____ and _____. - Anti-B antibodies prevent donation from type B and type AB. HLA Typing - Microcytotoxicity test Tests for MHC _____ Test hundreds of different haplotypes to find a potential match. Cells recognized by antibody will be attacked by complement and thus become leaky and take up dye. HLA Typing - Mixed lymphocyte reaction Tests for MHC class _____ Take donor cells and irradiate them (prevent proliferation). Irradiated cells are mixed with donor cells to see if proliferation occurs. Higher radioactivity (thymidine) signifies _____ compatibility.