Signal Transduction — Flashcards

Once nitric oxide diffuses into muscle cells, it activates soluble (cytosolic) guanylyl cyclase, which converts _____ to cGMP

The alpha subunit of G proteins has intrinsic _____ activity and may bind GDP (inactive) or GTP (active)

Glucagon, cortisol, and epinephrine induce _____ leading to phosphorylation of serine / threonine residues of the insulin receptor and IRS-1

p53 induces apoptosis by activating _____ and BAK, which dimerize and form a pore in the outer mitochondrial membrane

Once the mitochondrial membrane has been made permeable, _____ can leak out and activate initiator caspases

Inhibition of Gi via the pertussis toxin results in _____ levels of cAMP

NF-kB activation pathway: Ubiquitination of IkB results in destruction of _____ and release of the NF-kB transcription factor

Gq proteins _____ the IP3-DAG signaling cascade

Gi proteins _____ the cAMP signaling cascade

PTCH1 is a membrane receptor and a _____ regulator of the Hedgehog signaling pathway.

Hint: positive/negative