MAP Kinase Cascades — Flashcards

Caspase _____ and 10 (Extrinsic pathway) and Caspase _____ (Intrinsic pathway) are initiators of Apoptosis

_____ protein inhibits the extrinsic pathway of apoptosis, which is mediated by the death receptor.

Which caspase is activated in intrinsic pathway of apoptosis (in response to ER stress)?_____

NF-kB activation pathway: IkB kinase phosphorylates the _____ complex, leading to ubiquitination of IkB

In the phospholipase C mechanism of cellular signaling, _____ and diacylglycerol (DAG) activate protein kinase C, which phosphorylates specific proteins to produce physiologic actions

A common Ras pathway mutation results in mutations of GAP, resulting in a lack of _____ to GDP inactivation

Growth factor binding to receptor results in Ras replacing _____ with GTP

The events that occur during the activation of GPCR are as follows: No answer _____

Cyclin _____ and Cyclin E-CDK2 drive cells from G1 to S phase

Cyclin _____ and Cyclin A-CDK1 are active in S phase