Insulin Signaling Pathway — Flashcards

_____ of the insulin receptor allows binding of insulin receptor substrate 1 (IRS-1)

NF-kB activation pathway: IkB kinase phosphorylates the _____ complex, leading to ubiquitination of IkB

The most important of the somatomedins is _____, also known as IGF-1

In the first step of the adenylyl cyclase and phospholipase C mechanism of signaling, binding of hormone to its receptor causes release of _____ from its subunit (s, i, or aq) and replacement by GTP

PTCH1 is a membrane receptor and a _____ regulator of the Hedgehog signaling pathway.

Hint: positive/negative

Glycogen phosphorylase is regulated by positive feedback by _____ via the alpha receptor (liver and muscle)

The events that occur during the activation of GPCR are as follows: No answer _____

Cyclin _____ and Cyclin A-CDK1 are active in S phase

Cyclin _____ and Cyclin E-CDK2 drive cells from G1 to S phase

_____ is the only known member of the CX3C chemokine group.