Molecular Biology and Genomics — Flashcards

_____ is a tumor suppressor gene that encodes a transcription factor which regulates urogenital development

p53 restricts the cell cycle to G1 by engendering the inhibition of _____, maintaining the hypophosphorylated state of Rb

In epigenetics, when a histone is _____ by an HDAC (an "eraser"), the histone winds the DNA to make it unavailable for transcription

At its core, CRISPR/Cas9 utilizes an endonuclease (_____) and a guide RNA that binds to a complementary target DNA sequence

An _____ is a chromosome with two copies of one arm and no copies of the other

_____ mosaicism occurs when a mutation arises from mitotic errors after fertilization and propagates through multiple tissues or organs

In epigenetics, when a histone is _____, the histone unwinds the DNA to make it available for transcription

Translocation of the ribosome during translation moves peptidyl tRNA from the _____ site to the P site

BRCA_____ is located on chromosome 13.

What gene sequence mutations are the most common cause of β⁰-thalassemia?