Interorgan Metabolite Exchange — Flashcards

Glucagon acts on the _____ (primarily) and adipose tissue

After three days of starvation, the main source of energy for the brain becomes _____ from adipose stores

Urea cycle and Krebs cycle are linked at _____

Increased glucagon (fasting) leads to increased cAMP and protein kinase A, thus _____ activity of FBPase-2 and decreasing activity of PFK-2

In starvation, the enzyme 5'-deiodinase is _____ in tissues such as skeletal muscle, but not inhibited in the other tissues, such as the brain

In a person starving for more than 18 hours, the source of energy is _____.

Effect of diabetes on hepatic glycolysis: no answer _____ - No PFK-2 due to lack of insulin - No glucose trapping in liver leads to elevated blood glucose (hyperglycemia)

Glucagon causes _____ fatty acid synthesis and increased lipolysis, which shunts substrates towards gluconeogenesis

Increased NADH/NAD+ (e.g. due to ethanol) causes increased conversion of _____ -> malate, thus preventing gluconeogenesis